Molecular cloning of the human histamine H2 receptor

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Molecular cloning of the human histamine H2 receptor.

We utilized the technique of polymerase chain reaction with oligonucleotide primers based upon the nucleotide sequence of the canine H2 histamine receptor gene which we recently isolated to clone its human homologue. Transfection of a construct of this gene in Colo-320 DM cells led to the expression of a receptor that bound to [methyl-3H] tiotidine and was linked to 3',5'cyclic adenosine monoph...

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[Structural analysis of the histamine H2 receptor].

In gastric parietal cells the histamine H2 receptor is involved in gastric acid secretion. Molecular cloning of the cDNA for the histamine H2 receptor has revealed that the receptor is a member of the G-protein coupled receptor family. We expressed histamine H2 receptors in CHO cells, COS7 cells, and Sf9 cells to analyze N-glycosylation, palmitoylation, and desensitization of the H2 receptor, w...

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Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.

Agonist-induced internalization of G protein-coupled receptors (GPCRs) has been implicated in receptor desensitization, resensitization, and down-regulation. In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization. We further studied the mechanisms involved and its potential r...

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In vitro radioprotective effects of histamine H2 receptor antagonist against gamma-rays induced chromosomal aberrations in human lymphocytes.

Background: Radioprotective capability of histamine H2 receptor antagonists have been shown in several in vivo studies mainly using animal models. However, to verify the effectiveness of these agents in clinical applications, studies should be performed on human cells. In the present study radioprotective properties of these agents was examined in vitro on human lymphocytes using metaphase anal...

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Cloning and functional expression of the human histamine H3 receptor.

Histamine regulates neurotransmitter release in the central and peripheral nervous systems through H3 presynaptic receptors. The existence of the histamine H3 receptor was demonstrated pharmacologically 15 years ago, yet despite intensive efforts, its molecular identity has remained elusive. As part of a directed effort to discover novel G protein-coupled receptors through homology searching of...

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ژورنال

عنوان ژورنال: Biochemical and Biophysical Research Communications

سال: 1991

ISSN: 0006-291X

DOI: 10.1016/0006-291x(91)91047-g